Elevated circulating tumor cells and squamous cell carcinoma antigen levels predict poor survival for patients with locally advanced cervical cancer treated with radiotherapy

Autor: Li-Si Zeng, Tian-Tian Cheng, Xiao-Long Chen, Yue-Feng Wen, Hai-hua Peng, Tong-Chong Zhou, Xiao-Dan Lin, Wen-Jin Huang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
Colorectal cancer
medicine.medical_treatment
Cancer Treatment
Uterine Cervical Neoplasms
lcsh:Medicine
Cervical Cancer
Biochemistry
Mathematical and Statistical Techniques
0302 clinical medicine
Circulating tumor cell
Risk Factors
Medicine and Health Sciences
Stage (cooking)
lcsh:Science
Cervical cancer
Multidisciplinary
Statistics
Squamous Cell Carcinomas
Obstetrics and Gynecology
Chemoradiotherapy
Middle Aged
Neoplastic Cells
Circulating
Prognosis
030220 oncology & carcinogenesis
Physical Sciences
Disease Progression
Biomarker (medicine)
Female
Research Article
Adult
Clinical Oncology
medicine.medical_specialty
Radiation Therapy
Research and Analysis Methods
Carcinomas
Disease-Free Survival
03 medical and health sciences
Breast cancer
Antigens
Neoplasm
Diagnostic Medicine
Internal medicine
Biomarkers
Tumor
medicine
Humans
Statistical Methods
neoplasms
Serpins
Retrospective Studies
business.industry
lcsh:R
Cancers and Neoplasms
Biology and Life Sciences
medicine.disease
Radiation therapy
030104 developmental biology
Multivariate Analysis
Women's Health
lcsh:Q
Clinical Medicine
business
Gynecological Tumors
Biomarkers
Mathematics
Follow-Up Studies
Zdroj: PLoS ONE, Vol 13, Iss 10, p e0204334 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Objective To evaluate the prognostic effects of combining serum circulating tumor cells (CTCs) and squamous cell carcinoma antigen (SCC-Ag) levels on patients with locally advanced cervical cancer treated with radiotherapy. Methods Ninety-nine patients with locally advanced cervical cancer ([FIGO] stage IIB-IVA) undergoing radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) were identified. The association between serum CTC level and clinicopathological parameters was examined. Univariate and multivariate survival analyses were performed by using Cox's proportional hazards regression model. Results Elevated CTC and SCC-Ag levels were significantly associated with poor disease-free survival (DFS). Multivariate analysis suggest that serum CTC level, FIGO stage and serum SCC-Ag level were independent prognostic factors for two-year DFS. When CTC and SCC-Ag levels were combined into a new risk model to predict disease progression of cervical cancer patients, it performed a significantly better predictive efficiency compared with either biomarker alone. Conclusion Serum CTC and SCC-Ag levels are potentially useful biomarkers for prediction of prognosis in locally advanced cervical cancer patients and their combination significantly improves predictive ability for survival in locally advanced cervical cancer patients.
Databáze: OpenAIRE
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