The prognostic utility of the histologic subtype of stage I lung adenocarcinoma may be diminished when using only the invasive component to determine tumor size for tumor node metastasis (TNM) staging
| Autor: | Kyo Young Lee, Yeoun Eun Sung, Youngkyu Moon |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology medicine.medical_specialty Multivariate analysis Lung Tumor size business.industry Lymphovascular invasion TNM staging system medicine.disease digestive system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Stage I Lung Adenocarcinoma Internal medicine Medicine Adenocarcinoma Original Article business Tumor node metastasis |
| Zdroj: | J Thorac Dis |
| ISSN: | 2077-6624 2072-1439 |
| Popis: | BACKGROUND: Histologic subtypes were considered prognostic factors in early-stage lung adenocarcinoma in the 7(th) edition of the tumor node metastasis (TNM) staging system (TNM-7). However, the T-staging system has changed and now measures only the size of the invasive component to determine tumor size. The aim of this study was to determine whether the histologic subtype is still a prognostic factor in the 8(th) edition of the TNM staging system (TNM-8). METHODS: From 2010 to 2017, 788 patients who underwent curative surgery for stage I lung adenocarcinoma according to TNM-8 were analyzed retrospectively. Survival rates were compared among predominant patterns of adenocarcinoma. Prognostic factors were analyzed according to risk factors for recurrence in stage I lung adenocarcinoma. RESULTS: The 5-year recurrence-free survival rates among predominant histologic subtypes were statistically different, especially between the lepidic/acinar/papillary group and the micropapillary/solid group. Total tumor size was not significantly different between the two groups, but invasive component size was different (1.5 vs. 2.3 cm, P |
| Databáze: | OpenAIRE |
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