Clinical functional MRI of the language domain in children with epilepsy
| Autor: | Ingeborg Krägeloh-Mann, Tom Pieper, Thekla Dushe, Wolfgang Grodd, Hans Holthausen, Marko Wilke, Katja Lindner, Martin Staudt |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Decision Making Audiology Functional Laterality Lateralization of brain function Epilepsy Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Epilepsy surgery In patient Age of Onset Child Research Articles Language Cerebral Cortex Pediatric epilepsy Radiological and Ultrasound Technology medicine.diagnostic_test Confounding Electroencephalography Cortical dysplasia medicine.disease Magnetic Resonance Imaging Neurology Child Preschool Data Interpretation Statistical Wada test Anticonvulsants Female Neurology (clinical) Anatomy Psychology Neuroscience |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1065-9471 |
| DOI: | 10.1002/hbm.21156 |
| Popis: | Functional MRI (fMRI) for the assessment of language functions is increasingly used in the diagnostic workup of patients with epilepsy. Termed “clinical fMRI,” such an approach is also feasible in children who may display specific patterns of language reorganization. This study was aimed at assessing language reorganization in pediatric epilepsy patients, using fMRI. We studied 26 pediatric epilepsy patients (median age, 13.05 years; range, 5.6–18.7 years) and 23 healthy control children (median age, 9.37 years; range, 6.2–15.4 years), using two child‐friendly fMRI tasks and adapted data‐processing streams. Overall, 81 functional series could be analyzed. Reorganization seemed to occur primarily in homotopic regions in the contralateral hemisphere, but lateralization in the frontal as well as in the temporal lobes was significantly different between patients and controls. The likelihood to find atypical language organization was significantly higher in patients. Additionally, we found significantly stronger activation in the healthy controls in a primarily passive task, suggesting a systematic confounding influence of antiepileptic medication. The presence of a focal cortical dysplasia was significantly associated with atypical language lateralization. We conclude that important confounds need to be considered and that the pattern of language reorganization may be distinct from the patterns seen in later‐onset epilepsy. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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