Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code
| Autor: | Igor Maksimovic, Yael David |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Chemistry Chemical biology Lipid-anchored protein Biochemistry Article Chromatin In vitro Cell biology Histone Code Histones 03 medical and health sciences 0302 clinical medicine Covalent bond Histone code Epigenetics Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology Macromolecule |
| Zdroj: | Trends Biochem Sci |
| ISSN: | 0968-0004 |
| Popis: | The interior of the cell abounds with reactive species that can accumulate as non-enzymatic covalent modifications (NECMs) on biological macromolecules. These adducts interfere with many cellular processes, for example by altering proteins’ surface topology, enzymatic activity or interactomes. Here, we discuss dynamic NECM modifications on chromatin, which serves as the cellular blueprint. We first outline the chemistry of NECM formation and then focus on the recently identified effects of their accumulation on chromatin structure and transcriptional output. We next describe the known cellular regulatory mechanisms that prevent or reverse NECM formation. Finally, we discuss recently developed chemical biology platforms for probing and manipulating these NECMs in vitro and in vivo. |
| Databáze: | OpenAIRE |
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