In search of new anticancer drugs: Data for cytotoxic activities of green synthesized silver nanoparticles from ethanolic extracts of fruits and leaves of Annona muricata and 5-Fluorouracil against HeLa, PC3 and PNT1A cell lines
| Autor: | Yahaya Gavamukulya, Amos M. Meroka, Hany A. El-Shemy, Esther N. Maina, Gabriel Magoma, Fred Wamunyokoli |
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| Rok vydání: | 2019 |
| Předmět: |
Resazurin
Cytotoxicity lcsh:Computer applications to medicine. Medical informatics Silver nanoparticle HeLa 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine PC3 Biochemistry Genetics and Molecular Biology Viability assay lcsh:Science (General) Annona muricata 030304 developmental biology 0303 health sciences Multidisciplinary biology PNT1A Silver nanoparticles (AgNPs) biology.organism_classification chemistry Biochemistry Cell culture lcsh:R858-859.7 Growth inhibition 030217 neurology & neurosurgery lcsh:Q1-390 5FU |
| Zdroj: | Data in Brief Data in Brief, Vol 26, Iss, Pp-(2019) |
| ISSN: | 2352-3409 |
| DOI: | 10.1016/j.dib.2019.104442 |
| Popis: | In this article, we present data on the anticancer activities of green synthesized silver nanoparticles (AgNPs) from ethanolic extracts of fruits (AgNPs-F) and leaves (AgNPs-L) of Annona muricata and standard anticancer drug 5-Fluorouracil (5-FU) on two cancer cell lines, i.e. cervical adenocarcinoma (HeLa cells) and prostate adenocarcinoma (PC3 cells) as well as on an immortalized normal prostate cell line, PNT1A. The cytotoxicity on the cells was determined by measuring the absorbance signal of resazurin dye. It has long been known that metabolically active cells change the resazurin from blue (oxidized) to red (reduced) forms, corresponding to the absorbance signals at a wavelength of 570nm (A570) and 600nm (A600) respectively, from which therefore the effects of any treatments on percentage cell viability/death can be elucidated. The raw data values of the treatments against the HeLa, PC3 and PNT1A cells are shown in the different Tables. Examples of how the data can be analyzed have been illustrated using different growth inhibition curves. The data can be used by academics, students, and researchers working on development of anticancer drugs. Keywords: Silver nanoparticles (AgNPs), 5FU, HeLa, PC3, PNT1A, Cytotoxicity, Resazurin |
| Databáze: | OpenAIRE |
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