Occurrence of the nitrosamide precursor pyrrolidin-(2)-one in food and tobacco
| Autor: | R. Preussmann, Bertold Spiegelhalder, P. Mende, D. Ziebarth |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cacao
Cancer Research Chromatography General Medicine Hydrogen-Ion Concentration Coffee Mass Spectrometry Pyrrolidinones Pyrrolidin 2 one law.invention Plants Toxic chemistry.chemical_compound chemistry Biochemistry law Tobacco Nitrosation Gas chromatography Nitrite Food Analysis Carcinogen Nitrosamide Nitroso Compounds Chemiluminescence |
| Zdroj: | Carcinogenesis. 15:733-737 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/15.4.733 |
| Popis: | Pyrrolidinone was identified in food and tobacco samples by gas chromatography combined with NO-specific chemiluminescence detection (TEA). Up to 77 mg/kg pyrrolidinone were detected in cocoa powders, coffee, coffee surrogates, dried vegetables and tobacco leaves. When treated with excess nitrite under acidic conditions, N-nitrosopyrrolidinone was formed in concentrations up to 44 mg/kg. The nitrosation characteristics of pyrrolidinone indicate its possible conversion to nitrosopyrrolidinone under conditions of the gastric tract. |
| Databáze: | OpenAIRE |
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