Levels-of-Processing Effect on Frontotemporal Function in Schizophrenia During Word Encoding and Recognition
| Autor: | Ruben C. Gur, Stephen J. Kanes, Jeffrey N. Valdez, Raquel E. Gur, James Loughead, J. Daniel Ragland, Stephen T. Moelter, Christian G. Kohler, Mark A. Elliott, Steven J. Siegel |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Prefrontal Cortex Neuropsychological Tests Verbal learning Hippocampus Functional Laterality Article Lingual gyrus Thalamus medicine Humans Levels-of-processing effect Prefrontal cortex Episodic memory Brain Mapping medicine.diagnostic_test Recognition Psychology Verbal Learning Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Semantics Oxygen Psychiatry and Mental health Frontal lobe Word recognition Schizophrenia Female Schizophrenic Psychology Psychology Functional magnetic resonance imaging Neuroscience Psychomotor Performance Cognitive psychology |
| Zdroj: | American Journal of Psychiatry. 162:1840-1848 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/appi.ajp.162.10.1840 |
| Popis: | Patients with schizophrenia improve episodic memory accuracy when given organizational strategies through levels-of-processing paradigms. This study tested if improvement is accompanied by normalized frontotemporal function.Event-related blood-oxygen-level-dependent functional magnetic resonance imaging (fMRI) was used to measure activation during shallow (perceptual) and deep (semantic) word encoding and recognition in 14 patients with schizophrenia and 14 healthy comparison subjects.Despite slower and less accurate overall word classification, the patients showed normal levels-of-processing effects, with faster and more accurate recognition of deeply processed words. These effects were accompanied by left ventrolateral prefrontal activation during encoding in both groups, although the thalamus, hippocampus, and lingual gyrus were overactivated in the patients. During word recognition, the patients showed overactivation in the left frontal pole and had a less robust right prefrontal response.Evidence of normal levels-of-processing effects and left prefrontal activation suggests that patients with schizophrenia can form and maintain semantic representations when they are provided with organizational cues and can improve their word encoding and retrieval. Areas of overactivation suggest residual inefficiencies. Nevertheless, the effect of teaching organizational strategies on episodic memory and brain function is a worthwhile topic for future interventional studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|