Serum Ceruloplasmin, Plasma Copper Concentration and Copper to Ceruloplasmin Ratio in Cervical Carcinoma
| Autor: | R. Swaminathan, Michael S. Rogers, Mano Arumanayagam, Felix Wong |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Uterine Cervical Neoplasms chemistry.chemical_element Internal medicine Cervical carcinoma Biomarkers Tumor medicine Carcinoma Humans Neoplasm Staging Cervical cancer Analysis of Variance biology Epithelioma business.industry Ceruloplasmin Obstetrics and Gynecology Cancer Middle Aged medicine.disease Copper Pathophysiology Endocrinology Reproductive Medicine chemistry biology.protein Female business |
| Zdroj: | Gynecologic and Obstetric Investigation. 35:175-178 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000292694 |
| Popis: | Several studies have shown that plasma/serum copper and ceruloplasmin concentrations are increased in various carcinomas. We determined serum concentrations of ceruloplasmin and plasma copper concentration to evaluate the clinical usefulness of these tests in patients with cervical carcinomas. There was a significantly higher ceruloplasmin concentration in patients with cervical carcinoma compared to healthy controls. Plasma concentrations of copper were not significantly different in the two groups of subjects. The copper to ceruloplasmin ratio was lower in cancer patients than in control subjects. There was a significant increase in the serum concentrations of ceruloplasmin with increasing FIGO stage of cancer. Copper concentration in advanced tumours (FIGO stage 3) were significantly higher compared to control subjects or FIGO 1 and 2. Copper to ceruloplasmin ratio was lower in FIGO stage 2 and 3 patients compared to stage 1 or control subjects. Ceruloplasmin can also discriminate between large tumours which are inoperable and early cervical carcinomas better than copper or copper to ceruloplasmin ratio. |
| Databáze: | OpenAIRE |
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