Role of magnetic resonance imaging in characterization of central nervous system lesions in pediatric patients with leukemia and post-treatment complications
| Autor: | Hamada Khater, Ayda Youssef, Marwa Romeih, Ahmed Youssef, Eman M. Amer |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Acute leukemia medicine.medical_specialty Leukemia medicine.diagnostic_test business.industry lcsh:R895-920 Central nervous system Magnetic resonance imaging Disease medicine.disease medicine.anatomical_structure Pharmacotherapy Medicine Radiology Nuclear Medicine and imaging Radiology Post treatment CNS business Adverse effect |
| Zdroj: | The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-14 (2020) |
| ISSN: | 2090-4762 |
| DOI: | 10.1186/s43055-020-00337-5 |
| Popis: | Background Leukemia is one of the most common fatal diseases in pediatric oncology. Recently, advances in drug therapy have improved the prognosis of acute leukemia with event-free survival of up to 60%; however, complications and adverse effects of the disease and anti-leukemic treatment have also increased. The CNS complications of leukemia can be classified into those that developed directly or indirectly from the underlying leukemic process and those that can be related to antileukemic therapy. MRI had improved early detection of CNS complications and proper management. The study aims to characterize the MRI findings caused by the leukemic involvement of CNS structures and treatment-associated CNS complications and assess its value in early management and avoidance of long-term side effects. Results The patient’s age ranged from 2 to 18 years with different types of leukemia classified regarding the time of presentation as pretreatment, during treatment phases, and post-treatment. Different MRI abnormalities were recorded and clinically correlated. Conclusion The neurological complications of leukemia have common presenting symptoms but varying imaging abnormalities. To reach the correct diagnosis, the presenting signs, symptoms, and laboratory data must be considered along with the radiologic findings. A diagnostic algorithm using conventional, post-contrast MRI, MR venography, along with diffusion-weighted MRI was of great value in early detection and differentiation of different CNS lesions detected in pediatric patients with leukemia and post-treatment CNS complications. |
| Databáze: | OpenAIRE |
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