Tail approach synthesis of triazolylthiazolotriazole bearing benzenesulfonamides as carbonic anhydrase inhibitors capable of inducing apoptosis

Autor:	Lalit Vats, Kiran Siwach, Andrea Angeli, Prerna Bikal, Jitender Kumar Bhardwaj, Claudiu T. Supuran, Pawan K. Sharma
Rok vydání:	2022
Předmět:	Drug Discovery Pharmaceutical Science
Zdroj:	Archiv der PharmazieREFERENCES.
ISSN:	1521-4184
Popis:	Inhibition of human carbonic anhydrase (hCA) isoform IX with concurrent induction of apoptosis is a promising approach for targeting cancer in humans. Prompted by the scope, novel benzenesulfonamides containing the 1,2,3-triazolylthiazolotriazole tail were synthesized and screened as inhibitors of hCA isoforms I, II, IV, and IX. The tumor-associated isoform hCA IX was strongly inhibited by the sulfonamides reported here with K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00478373e901bd92d9dd4555038d8eef https://pubmed.ncbi.nlm.nih.gov/36344431 Zobrazit plný text záznamu Plný text