Tail approach synthesis of triazolylthiazolotriazole bearing benzenesulfonamides as carbonic anhydrase inhibitors capable of inducing apoptosis
Autor: | Lalit Vats, Kiran Siwach, Andrea Angeli, Prerna Bikal, Jitender Kumar Bhardwaj, Claudiu T. Supuran, Pawan K. Sharma |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Archiv der PharmazieREFERENCES. |
ISSN: | 1521-4184 |
Popis: | Inhibition of human carbonic anhydrase (hCA) isoform IX with concurrent induction of apoptosis is a promising approach for targeting cancer in humans. Prompted by the scope, novel benzenesulfonamides containing the 1,2,3-triazolylthiazolotriazole tail were synthesized and screened as inhibitors of hCA isoforms I, II, IV, and IX. The tumor-associated isoform hCA IX was strongly inhibited by the sulfonamides reported here with K |
Databáze: | OpenAIRE |
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