The influence of selected ω-mercaptocarboxylate ligands on physicochemical properties and biological activity of Cd-free, zinc‑copper‑indium sulfide colloidal nanocrystals
| Autor: | Marcin Drozd, Mariusz Pietrzak, Ilona Grabowska-Jadach, Zbigniew Brzozka, Elżbieta Malinowska, Artur Dybko, Dominika Kalinowska |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Sulfide Cell Survival chemistry.chemical_element Apoptosis Bioengineering 02 engineering and technology Zinc Sulfides Ligands 010402 general chemistry Photochemistry Indium 01 natural sciences Fluorescence spectroscopy Cell Line Biomaterials Colloid Ultraviolet visible spectroscopy Quantum Dots Humans Colloids Picolinic Acids 3-Mercaptopropionic Acid chemistry.chemical_classification Microscopy Confocal Ligand technology industry and agriculture equipment and supplies 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Mechanics of Materials Quantum dot Surface modification Reactive Oxygen Species 0210 nano-technology Copper |
| Zdroj: | Materials Science and Engineering: C. 97:583-592 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2018.12.043 |
| Popis: | In this work core/shell cadmium-free zinc‑copper‑indium sulfide ZnCuInS/ZnS quantum dots (QDs) originally stabilized with hydrophilic alkanethiol were modified with 3-mercaptopropionic acid (MPA) or 6-mercaptohexanoic acid (MHA) via two-step ligand exchange method. The obtained QDs were further characterized by TEM, UV Vis, and fluorescence spectroscopy. Both types of QDs were non-toxic in a wide range of concentrations. To our knowledge, our studies are the first attempt to determine the type of cell death and reactive oxygen species production level as a result of incubation of cell cultures with ZnCuInS/ZnS QDs. Furthermore, the accumulation of QDs in vitro was examined on three human cell lines by fluorescence intensity measurements and visualized by confocal microscopy. The modification of QDs with a ligand characterized by slightly longer aliphatic chain (MHA), instead of typically used MPA turns out to be beneficial both from the point of colloidal stability, preservation of optical properties during ligand exchange as well as reflects in a higher cellular uptake. This contribution can be beneficial from the point of view of the selection of the optimal ligands and concentrations in the case of ZnCuInS/ZnS core-shell QDs for biological applications. |
| Databáze: | OpenAIRE |
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