Allogeneic Hematopoietic Cell Transplant for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome

Autor:	Hemalatha G. Rangarajan, Nicole Davidson, Rolla Abu-Arja, Rajinder P.S. Bajwa, Veronika Polishchuk, Kyla Driest
Rok vydání:	2021
Předmět:	030203 arthritis & rheumatology 0301 basic medicine business.industry Hepatosplenomegaly Arthritis Case Report Diseases of the musculoskeletal system General Medicine medicine.disease Rash 03 medical and health sciences 030104 developmental biology 0302 clinical medicine RC925-935 Refractory Macrophage activation syndrome Immunology medicine Juvenile medicine.symptom Complication business Serositis
Zdroj:	Case Reports in Rheumatology, Vol 2021 (2021) Case Reports in Rheumatology
ISSN:	2090-6897 2090-6889
DOI:	10.1155/2021/9323141
Popis:	Systemic juvenile idiopathic arthritis (sJIA) is characterized by arthritis, fever, rash, lymphadenopathy, hepatosplenomegaly, and serositis. Macrophage activation syndrome is the most feared complication of sJIA with a high risk of mortality. We report a 16-year-old female diagnosed with refractory systemic juvenile idiopathic arthritis (sJIA) complicated by recurrent macrophage activation syndrome (MAS), severe joint disease, and lung involvement requiring prolonged immunosuppressive therapy. She received a matched unrelated allogeneic hematopoietic cell transplant (Allo-HCT) using a reduced-intensity conditioning regimen and is now, 3 years after the transplant, with complete resolution of sJIA symptoms, off immunosuppressants, and with significant improvement in the quality of life.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0045645522e50035232799a8ea82c8f5 https://doi.org/10.1155/2021/9323141 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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