Bleeding tendency and platelet function during treatment with romiplostim in children with severe immune thrombocytopenic purpura

Autor:	Galina Novichkova, Juliya Dobrynina, Nikolay M. Ershov, Zhanna S. Supik, Ekaterina V. Orekhova, Aleksey V. Pshonkin, Aleksey Maschan, Anastasia A. Ignatova, Mikhail A. Panteleev, Lili A. Hachatryan, Irina V. Serkova, Elena V. Suntsova, Natalia N. Kotskaya, Irina M. Demina, Natalia M. Trubina
Rok vydání:	2017
Předmět:	Blood Platelets Male Adolescent Recombinant Fusion Proteins Eltrombopag Thrombopoietin mimetics Hemorrhage Receptors Fc Benzoates 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antigens CD Humans Medicine Platelet Annexin A5 Mean platelet volume Child Whole blood Purpura Thrombocytopenic Idiopathic Romiplostim Platelet Count business.industry Infant Hematology medicine.disease Thrombocytopenic purpura Hydrazines Thrombopoietin chemistry Child Preschool 030220 oncology & carcinogenesis Immunology Pyrazoles Female business CD61 Receptors Pituitary Adenylate Cyclase-Activating Polypeptide Type I 030215 immunology medicine.drug
Zdroj:	International Journal of Hematology. 105:841-848
ISSN:	1865-3774 0925-5710
Popis:	It has been suggested that platelet function in chronic immune thrombocytopenic purpura (ITP) may be abnormal. Thrombopoietin mimetics used for treatment can affect it, but the data remain limited. We investigated platelet function of 20 children diagnosed with severe ITP (aged 1–16 years, 12 females and eight males). Platelet functional activity in whole blood was characterized by flow cytometry before and after stimulation with SFLLRN plus collagen-related peptide. Levels of CD42b, PAC1, and CD62P, but not CD61 or annexin V, were significantly increased (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044d12b48db5887b8659a4254ffb5ac https://doi.org/10.1007/s12185-017-2207-3 Zobrazit plný text záznamu Full text from SpringerLink