Secondhand smoke exposure and survival following acute coronary syndrome: prospective cohort study of 1261 consecutive admissions among never-smokers
| Autor: | Paul D MacIntyre, F G Dunn, Brian O’Rourke, W. Borland, Jill P. Pell, Keith G. Oldroyd, Colin Fischbacher, Stuart M. Cobbe, Stuart D. Pringle, Sally Haw, Alastair C H Pell, David E. Newby, David Murdoch |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Myocardial Infarction chemistry.chemical_compound Internal medicine Epidemiology medicine Humans Myocardial infarction Prospective Studies Acute Coronary Syndrome Secondhand smoke Prospective cohort study Cotinine Aged Aged 80 and over business.industry Environmental Exposure Middle Aged medicine.disease Prognosis Surgery Never smokers chemistry Scotland Epidemiological Monitoring Female Tobacco Smoke Pollution Cardiology and Cardiovascular Medicine business Biomarkers Cohort study Environmental Monitoring |
| Zdroj: | Heart (British Cardiac Society). 95(17) |
| ISSN: | 1468-201X |
| Popis: | Objective: To determine whether exposure to secondhand smoke is associated with early prognosis following acute coronary syndrome. Design, setting and participants: We interviewed consecutive patients admitted to nine Scottish hospitals over 23 months. Information was obtained, via questionnaire, on age, sex, smoking status, postcode of residence and admission serum cotinine concentration was measured. Follow-up data were obtained from routine hospital admission and death databases. Results: Of the 5815 participants, 1261 were never-smokers. Within 30 days, 50 (4%) had died and 35 (3%) had a non-fatal myocardial infarction. All-cause deaths increased from 10 (2.1%) in those with cotinine ⩽0.1 ng/ml to 22 (7.5%) in those with cotinine >0.9 ng/ml (χ 2 test for trend p 0.9 ng/ml: adjusted OR 4.80, 95% CI 1.95 to 11.83, p = 0.003). The same dose response was observed for cardiovascular deaths and death or myocardial infarction. Conclusions: Secondhand smoke exposure is associated with worse early prognosis following acute coronary syndrome. Non-smokers need to be protected from the harmful effects of secondhand smoke. |
| Databáze: | OpenAIRE |
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