The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens
| Autor: | Olga A. Snytnikova, Robert Kaptein, A. Zh. Fursova, N. A. Stefanova, Nataliya G. Kolosova, Renad Z. Sagdeev, Yu. P. Tsentalovich |
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| Rok vydání: | 2012 |
| Předmět: |
Cistanche
Antioxidant Plastoquinone medicine.medical_treatment Cistanche deserticola Biophysics Pharmacology medicine.disease_cause Biochemistry Antioxidants Cataract chemistry.chemical_compound Lens Crystalline medicine Animals Rats Wistar Kynurenine biology Therapeutic effect Tryptophan General Chemistry General Medicine biology.organism_classification Mitochondria Rats Treatment Outcome medicine.anatomical_structure chemistry Lens (anatomy) Oxidative stress Drugs Chinese Herbal |
| Zdroj: | Doklady Biochemistry and Biophysics. 447:300-303 |
| ISSN: | 1608-3091 1607-6729 |
| Popis: | Supplementation of senescence-accelerated OXYS rats with the mitochondria-targeted antioxidant SkQ1 and with the powder from Cistanche deserticola results in the deceleration of the cataract development and even in the improvement of lens transparency. The therapeutic effect of these preparations correlates with a significant elevation of tryptophan and kynurenine levels in the lens. This finding is attributed to a deceleration of the tryptophan and kynurenine oxidation due to antioxidant-assisted reduction of oxidative stress in the lens. |
| Databáze: | OpenAIRE |
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