Controllable Drug Delivery by Na+/K+ ATPase α1 Targeting Peptide Conjugated DSPE-PEG Nanocarriers for Breast Cancer
| Autor: | Yongsheng Yu, Yayan Yang, Chuanfeng Ding, Wei Kang, Qian Feng, Xiufeng Xiao, Qian Zhou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
NKA-α1 Anthracycline Cell Survival medicine.medical_treatment Peptide Breast Neoplasms 02 engineering and technology Nanoconjugates Targeted therapy Polyethylene Glycols 03 medical and health sciences Mice 0302 clinical medicine Breast cancer breast cancer In vivo Cell Movement Cell Line Tumor medicine Animals Humans RC254-282 chemistry.chemical_classification Antibiotics Antineoplastic Chemistry Phosphatidylethanolamines Neoplasms. Tumors. Oncology. Including cancer and carcinogens Epithelial Cells 021001 nanoscience & nanotechnology medicine.disease targeted therapy epirubicin peptide Oncology 030220 oncology & carcinogenesis Drug delivery Liposomes Cancer research Female Original Article Nanocarriers Sodium-Potassium-Exchanging ATPase 0210 nano-technology Epirubicin medicine.drug |
| Zdroj: | Technology in Cancer Research & Treatment Technology in Cancer Research & Treatment, Vol 20 (2021) |
| ISSN: | 1533-0338 |
| Popis: | Although Epirubicin (EPI) is a commonly used anthracycline for the treatment of breast cancer in clinic, the serious side effects limit its long-term administration including myelosuppression and cardiomyopathy. Nanomedicines have been widely utilized as drug delivery vehicles to achieve precise targeting of breast cancer cells. Herein, we prepared a DSPE-PEG nanocarrier conjugated a peptide, which targeted the breast cancer overexpression protein Na+/K+ ATPase α1 (NKA-α1). The nanocarrier encapsulated the EPI and grafted with the NKA-α1 targeting peptide through the click reaction between maleimide and thiol groups. The EPI was slowly released from the nanocarrier after entering the breast cancer cells with the guidance of the targeting NKA-α1 peptide. The precise and controllable delivery and release of the EPI into the breast cancer cells dramatically inhibited the cells proliferation and migration in vitro and suppressed the tumor volume in vivo. These results demonstrate significant prospects for this nanocarrier as a promising platform for numerous chemotherapy drugs. |
| Databáze: | OpenAIRE |
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