Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy
| Autor: | JC Biggs, MM Horowitz, RP Gale, RC Ash, K Atkinson, W Helbig, N Jacobsen, GL Phillips, AA Rimm, O Ringden |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Adolescent Immunology Remission Induction Drug Resistance Graft vs Host Disease Infant Cell Biology Hematology Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Biochemistry Survival Rate Leukemia Myeloid Acute hemic and lymphatic diseases Child Preschool Humans Female Child Bone Marrow Transplantation |
| Zdroj: | Blood. 80(4) |
| ISSN: | 0006-4971 |
| Popis: | About 30% of adults with acute lymphoblastic leukemia (ALL) and 20% to 40% of children and adults with acute myelogenous leukemia (AML) never achieve remission, even with intensive chemotherapy. Most die of resistant leukemia, often within 6 months or less. In this study of 126 patients with resistant ALL or AML, allogeneic bone marrow transplants from HLA-identical siblings produced remissions in 113 of 115 (98%) evaluable patients. The 3-year probability of leukemia-free survival was 21% (95% confidence interval, 15% to 29%). Leukemia-free survival was similar in ALL (23%, 12% to 40%) and AML (21%, 14% to 31%). Only 3 of 27 patients at risk relapsed more than 2 years posttransplant. |
| Databáze: | OpenAIRE |
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