Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon
| Autor: | Sowath Ly, Georges Alain Mballa Etoundi, Phalla Y, Richard Njouom, Erik A. Karlsson, Marie-Astrid Vernet, Marie-Claire Okomo, Njankouo Ripa Mohamadou, Chavely Gwladys Monamele, Sreyviseth Horm, Paul F. Horwood, Abel Wade, Jean-Marc Feussom, Aristide Stéphane Abah Abah, Sokhoun Yann, Philippe Dussart |
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| Přispěvatelé: | Service de Virologie [Yaounde], Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Ministère de l'élevage, des pêches et des industries animales = Ministry of livestock, fisheries and animal industries [Yaoundé] (MINEPIA), Laboratoire National de Santé Publique = National Laboratory of Public Health [Yaoundé] (LNSP), Ministère de la Santé Publique [Cameroun], James Cook University (JCU), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], This work was supported by Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services [grant number IDSEP 140020-04-00]. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Epidemiology Avian influenza medicine.disease_cause Poultry Disease Outbreaks MESH: Aged 80 and over MESH: Poultry Zoonoses Drug Discovery MESH: Animals Cameroon MESH: Disease Outbreaks Clade MESH: Phylogeny Phylogeny Aged 80 and over MESH: Aged Farmers MESH: Middle Aged Risk of infection Strain (biology) MESH: Influenza Human virus diseases General Medicine H5N1 Poultry farming Middle Aged Transmissibility (vibration) 3. Good health Africa Western Phylogeography Infectious Diseases Seroconversion MESH: Phylogeography MESH: Young Adult [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology surveillance Female MESH: Zoonoses Adult Adolescent MESH: Influenza A Virus H5N1 Subtype MESH: Farmers 030106 microbiology Immunology Biology MESH: Seroconversion Microbiology Article 03 medical and health sciences Young Adult MESH: Influenza in Birds Virology MESH: Africa Western Influenza Human medicine Animals Humans Africa Central Aged MESH: Adolescent MESH: Humans Influenza A Virus H5N1 Subtype outbreak business.industry Outbreak MESH: Adult MESH: Cameroon Influenza A virus subtype H5N1 MESH: Male MESH: Africa Central 030104 developmental biology Influenza in Birds Africa Parasitology business MESH: Female |
| Zdroj: | Emerging microbes & infections Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2019, 8 (1), pp.186-196. ⟨10.1080/22221751.2018.1564631⟩ Emerging Microbes & Infections |
| ISSN: | 2222-1751 |
| Popis: | International audience; From May 2016 to March 2017, 22 poultry outbreaks of avian influenza A(H5N1) were reported in Cameroon, mainly in poultry farms and live bird markets. No human cases were reported. In this study, we sought to describe the 2016 A (H5N1) outbreak strain and to investigate the risk of infection in exposed individuals. We find that highly pathogenic influenza subtype A(H5N1), clade 2.3.2.1c from Cameroon is closely related phylogenetically and antigenically to strains isolated in central and western Africa at the time. No molecular markers of increased human transmissibility were noted; however, seroconversion was detected in two poultry workers (1.5% of total screened). Therefore, the continued outbreaks of avian influenza in poultry and the risk of zoonotic human infection highlight the crucial need for continued and vigilant influenza surveillance and research in Africa, especially in areas of high poultry trade, such as Cameroon. |
| Databáze: | OpenAIRE |
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