Subacute oral toxicity of tetraethylene glycol and ethylene glycol administered to Wistar rats
| Autor: | C.I. Rühl-Fehlert, I. Ivens, L. Schladt, E. Bomhard, Eberhard Karbe |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Administration Oral Urine Toxicology Kidney Oxalate Pathology and Forensic Medicine Excretion chemistry.chemical_compound Oral administration Internal medicine medicine Animals Rats Wistar Dose-Response Relationship Drug Cell Biology General Medicine medicine.disease Surgery Rats Endocrinology medicine.anatomical_structure chemistry Toxicity Ethylene Glycols Female Ethylene glycol Kidney disease |
| Zdroj: | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 50(3) |
| ISSN: | 0940-2993 |
| Popis: | Summary A subacute toxicity study with administration of tetraethyleneglycol in dosages of 0-220-660-2000 mg/kg body weight to male and female Wistar rats via gavage was conducted in order to characterize a possible toxic action of this compound. The structurally related compound ethylene glycol is known to cause kidney toxicity. Therefore, special attention was paid to investigating possible toxic effects of tetraethylene glycol on this organ. In order to compare possible treatment-related effects of tetraethylene glycol with those known from ethylene glycol, a group of male and female rats was treated with 2000 mg ethylene glycol/kg body weight. Daily oral application of tetraethylene glycol over4 weeks was tolerated without toxic effects up to and including 2000 mg/kg body weight. Daily oral application of ethylene glycol over 4 weeksresulted in treatment-related effects on the kidneys. A slight decrease in the urinary excretion of potassium, calcium and phosphate (males), a diminished pH-value of the urine, and a slight increase in osmolality (females) were observed. In both sexes excretion of oxalate was significantly increased and microscopic examination of urinary sediment revealed calcium oxalate crystals. Kidney weights of males and females were slightly elevated. Histopathology revealed crystals in renal tubuli, renal pelvis, and urinary bladder; tubulopathy and epithelial hyperplasia within the renal pelvis were also observed. Therefore, the study confirmed the kidney as target forethylene glycol toxicity and gave no indications of tetraethylene glycol-induced toxic effects. |
| Databáze: | OpenAIRE |
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