| Popis: |
The present research work was aimed to investigate anti-inflammatory and analgesic activity of ethanolic extract of Asclepias curassavica L (EEAC) against Formalin Induced Paw licking, Tail Immersion test, Acetic acid writhing model, carrageenan-induced paw edema method, Egg Albumin-Induced Inflammation EEAC showed significant inhibition in the early phase compared to a late phase in Formalin Induced Paw licking and in Tail Immersion test EEAC at 500mg/kg produced highly significant and greater analgesic activity and in Acetic acid writhing model EEAC at dose 500mg/kg has shown significant reduction in several writing’s. In the carrageenan-induced paw edema method, EEAC produced a significant reduction in paw volume in the 4th hour, and in Egg albumin-induced inflammation showed significant inhibition in paw volume in the 4th hour respectively. The mean reaction time, percentage of early and late phases, and the number of writhing were measured. The paw volume was measured using a Digital plethysmometer well as Egg Albumin-Induced Inflammation. However, the present study did not include the tests for establishing the extract mechanism of action. Keywords: Asclepias curassavica L; Anti-inflammatory; Analgesic; Carrageenan; Indomethacin. |
