Quantitative modeling of the high-throughput production and in vivo kinetics of (drug-encapsulating) liposomes
| Autor: | Albert Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Drug
media_common.quotation_subject High-throughput screening Kinetics lcsh:Medicine Pharmacology Permeability In vivo Pharmacokinetics lcsh:Science In vivo kinetics media_common Drug Carriers Liposome Multidisciplinary Chemistry lcsh:R Liposomes Drug delivery Chemical Biology/Biomimetic Chemistry Biophysics Biotechnology/Protein Chemistry and Proteomics lcsh:Q Biotechnology/Bioengineering Drug carrier Research Article Extravasation of Diagnostic and Therapeutic Materials |
| Zdroj: | PLoS ONE, Vol 5, Iss 4, p e10280 (2010) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | In developing liposomes for in vivo use, it is important to design the liposomes to have optimal in vivo kinetics, and it is also necessary to identify optimal high-throughput production conditions for these liposomes. Previous work has not definitively established the general relationship between liposomes' configuration and composition, and their in vivo kinetics. Also, no straightforward method exists to calculate optimal liposome high-throughput production conditions for specific liposome compositions. This work presents first-principles quantitative correlations describing liposomes' in vivo drug leakage and vascular mass transfer kinetics. This work further presents a simple quantitative model relating specific liposome compositions to ideal high-throughput production parameters. The results have implications for the identification of promising liposome compositions via high-throughput screening methodologies, as well as the design and optimization of high-throughput reactors for liposome production. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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