Targeting of the Brucella suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen
| Autor: | Jean-Yves Winum, Jean-Louis Montero, Stephan Köhler, Pascale Joseph, Marie-Rose Abdo, Rose-Anne Boigegrain |
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| Přispěvatelé: | Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM) |
| Rok vydání: | 2007 |
| Předmět: |
Brucella suis
Virulence Factors Virulence MESH: Ketones Brucella Histidinol dehydrogenase Brucellosis MESH: Alcohol Oxidoreductases Virulence factor Cell Line Microbiology Structure-Activity Relationship MESH: Histidine 03 medical and health sciences MESH: Structure-Activity Relationship MESH: Brucellosis Histidinol Humans Histidine Pharmacology (medical) Enzyme Inhibitors Pathogen MESH: Brucella suis MESH: Virulence Factors 030304 developmental biology Pharmacology 0303 health sciences MESH: Humans biology 030306 microbiology Macrophages MESH: Macrophages Ketones biology.organism_classification Culture Media MESH: Cell Line Alcohol Oxidoreductases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Infectious Diseases Susceptibility MESH: Enzyme Inhibitors MESH: Culture Media MESH: Histidinol Brucella melitensis |
| Zdroj: | Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (10), pp.3752-5. ⟨10.1128/AAC.00572-07⟩ |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00572-07 |
| Popis: | Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of Brucella HDH activity. |
| Databáze: | OpenAIRE |
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