Extraskeletal Ewing's tumor with translocation t(11;22) in a patient with Down syndrome
| Autor: | Giorgio Ponzio, Luciano Fessia, Laura Casorzo, Gianni Bussolati, Anna Sapino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Adolescent Chromosomes Human Pair 22 Chromosomal translocation Soft Tissue Neoplasms Sarcoma Ewing Biology Translocation Genetic Genetics medicine Humans Molecular Biology Chromosomes Human Pair 11 Cytogenetics Ewing's tumor Karyotype medicine.disease Karyotyping Tetrasomy Sarcoma Down Syndrome Chromosome 21 Trisomy |
| Popis: | A case of a small cell malignant tumor that occurred in the soft tissues of a 16-year-old boy with Down syndrome (47,XY,+21) is reported. The histologic and histochemical patterns were consistent with an extraskeletal Ewing's sarcoma (ES). The cytogenetic analysis of the tumor cells showed a t(11;22)(q24;q21), tetrasomy of chromosome 21, and trisomy of chromosome 14. The observation of a t(11;22) in an ES gives credit to the morphologic evidence in favor of the common (probably neuroectodermal) origin of the skeletal and extraskeletal forms of Ewing's sarcoma (ES). The possible pathogenetic significance of the constitutional trisomy of chromosome 21 in determining the occurrence of this tumor is discussed. |
| Databáze: | OpenAIRE |
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