Active and passive avoidance learning in rats neonatally treated with intraventricular 6-hydroxydopamine
| Autor: | Miki Takasuna, Tsuneo Iwasaki |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.disease_cause Behavioral Neuroscience chemistry.chemical_compound Jumping Dopamine Avoidance Learning medicine Animals Biogenic Monoamines Oxidopamine Neurotransmitter Injections Intraventricular Brain Chemistry Electroshock Sex Characteristics Hydroxydopamine Sympathectomy Chemical Rats Inbred F344 Rats Animals Newborn chemistry Sensory Thresholds Anesthesia Catecholamine Female Passive avoidance Psychology Neuroscience Intraventricular Injections medicine.drug |
| Zdroj: | Behavioural Brain Research. 74:119-126 |
| ISSN: | 0166-4328 |
| Popis: | To clarify the behavioral characteristics of rats neonatally treated with 6-hydroxydopamine (6-OHDA), their performance on 4 aversive learning tasks, 3 active (shuttle, one-way, and rearing) avoidance tasks and one passive (step-through) avoidance task, was examined. On days 2 and 4 after birth, each rat of F344/Du strain received bilateral intraventricular injections of 6-OHDA (35 μg × 2) or vehicle solution following desmethylimipramine (20 mg/kg, s.c.) pretreatment. From day 90, each rat was trained in one of the 4 avoidance tasks. 6-OHDA-treated rats showed significantly less avoidance responses in the shuttle and the one-way avoidance tasks, but their performance on the rearing and the step-through passive avoidance tasks was not significantly different from that of control rats. The differential impairment of avoidance suggests that 6-OHDA treatment does not cause a general learning deficit, but facilitates rearing and/or jumping responses in aversive situations, which results in inappropriate escape responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect