Haploinsufficiency of VGluT1 but not VGluT2 impairs extinction of spatial preference and response suppression
| Autor: | Ilse Goris, Diederik Moechars, Guy Daneels, Detlef Balschun, Sandra Leo, Nathalie Van Acker, Rudi D'Hooge, Arne Naert, Theo Meert, Zsuzsanna Callaerts-Vegh |
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| Rok vydání: | 2013 |
| Předmět: |
Reinforcement Schedule
Emotions Appetite Hippocampus Water maze Striatum Inhibitory postsynaptic potential Extinction Psychological Mice Behavioral Neuroscience Glutamatergic Avoidance Learning medicine Animals Learning Maze Learning Brain Chemistry Mice Knockout Neocortex Behavior Animal Glutamate receptor Extinction (psychology) Immunohistochemistry Memory Short-Term medicine.anatomical_structure Space Perception Vesicular Glutamate Transport Protein 1 Vesicular Glutamate Transport Protein 2 Psychology Neuroscience |
| Zdroj: | Behavioural Brain Research. 245:13-21 |
| ISSN: | 0166-4328 |
| Popis: | The excitatory neurotransmitter l -glutamate is transported into synaptic vesicles by vesicular glutamate transporters (VGluTs) to transmit glutamatergic signals. Changes in their expression have been linked to various brain disorders including schizophrenia, Parkinson's, and Alzheimer's disease. Deleting either the VGluT1 or VGluT2 gene leads to profound developmental and neurological complications and early death, but mice heterozygous for VGluT1 or VGluT2 are viable and thrive. Acquisition, retention and extinction of conditioned visuospatial and emotional responses were compared between VGluT1 +/− and VGluT2 +/− mice, and their wildtype littermates, using different water maze procedures, appetitive scheduled conditioning, and conditioned fear protocols. The distinct brain expression profiles of the VGluT1 and -2 isoforms particularly in telencephalic structures, such as neocortex, hippocampus and striatum, are reflected in very specific behavioral changes. VGluT2 +/− mice were unimpaired in spatial learning tasks and fear extinction. Conversely, VGluT1 +/− mice displayed spatial extinction learning deficits and markedly impaired fear extinction. These data indicate that VGluT1, but not VGluT2, plays a role in the neural processes underlying inhibitory learning. |
| Databáze: | OpenAIRE |
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