Equivalent linear change in cognition between individuals with bipolar disorder and healthy controls over 5 years

Autor:	Shervin Assari, Rebecca Easter, Kristin H. Hinrichs, Scott A. Langenecker, Pallavi Babu, David F. Marshall, Kelly A. Ryan, Bethany Pester, Kaley Angers, Melvin G. McInnis
Rok vydání:	2017
Předmět:	Adult Male medicine.medical_specialty Bipolar Disorder Echoic memory Neuropsychological Tests Audiology Article Time Developmental psychology Cohort Studies Executive Function 03 medical and health sciences Cognition 0302 clinical medicine Visual memory Memory medicine Humans Longitudinal Studies Cognitive skill Bipolar disorder Effects of sleep deprivation on cognitive performance Biological Psychiatry Latent growth modeling Neuropsychology Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Disease Progression Female Cognition Disorders Psychology 030217 neurology & neurosurgery
Zdroj:	Bipolar Disorders. 19:689-697
ISSN:	1398-5647
Popis:	Objectives Cognitive dysfunction is a key feature of bipolar disorder (BD). However, not much is known about its temporal stability, as some studies have demonstrated a neurodegenerative model in BD while others have shown no change in cognitive functioning over time. Building upon our prior work, which examined the natural course of executive functioning, the current study aimed to investigate the natural course of memory, emotion processing, and fine motor dexterity over a 5-year period in BD and healthy control (HC) samples. Methods Using a 5-year longitudinal cohort, 90 individuals with BD and 17 HCs were administered a battery of neuropsychological tests at study baseline and at 1 and 5 years after study entry that captured four areas of cognitive performance: visual memory, auditory memory, emotion processing, and fine motor dexterity. Results Latent growth curve modeling showed no group differences in the slopes of any of the cognitive factors between the BD and HC groups. Age at baseline was negatively associated with visual memory, emotion processing, and fine motor dexterity. Education level was positively associated with auditory and visual memory and fine motor. Female gender was negatively associated with emotion processing. Conclusions Extending our prior work on longitudinal evaluation of executive functioning, individuals with BD show similar linear change in other areas of cognitive functioning including memory, emotion processing, and fine motor dexterity as compared to unaffected HCs. Age, education, and gender may have some differential effects on cognitive changes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003b68c9c69c9d2abda80fed1706e4f3 https://doi.org/10.1111/bdi.12532 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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