Designing of the Anticancer Nanocomposite with Sustained Release Properties by Using Graphene Oxide Nanocarrier with Phenethyl Isothiocyanate as Anticancer Agent
| Autor: | Palanisamy Arulselvan, Suresh Kumar Subbiah, Norhaizan Mohd Esa, Bullo Saifullah, Mohd Zobir Hussein, Sivapragasam Gothai, Dasan Mary Jaya Seema, M. Selvanayagam |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Drug
nano-carrier Phenethyl isothiocyanate media_common.quotation_subject Pharmaceutical Science lcsh:RS1-441 02 engineering and technology 010402 general chemistry anticancer 01 natural sciences Article law.invention lcsh:Pharmacy and materia medica chemistry.chemical_compound law media_common Nanocomposite nanocomposite Chemistry Graphene 021001 nanoscience & nanotechnology Combinatorial chemistry In vitro 0104 chemical sciences phenyisothiocyanate graphene oxide Nanocarriers 0210 nano-technology Drug carrier Conjugate |
| Zdroj: | Pharmaceutics, Vol 10, Iss 3, p 109 (2018) Pharmaceutics Volume 10 Issue 3 |
| ISSN: | 1999-4923 |
| Popis: | In this study anticancer nanocomposite was designed using graphene oxide (GO) as nanocarrier and Phenethyl isothiocyanate (PEITC) as anticancer agent. The designed formulation was characterized in detailed with XRD, Raman, UV/Vis, FTIR, DLS and TEM etc. The designed anticancer nanocomposite showed much better anticancer activity against liver cancer HepG2 cells compared to the free drug PEITC and was also found to be nontoxic to the normal 3T3 cells. In vitro release of the drug from the anticancer nanocomposite formulation was found to be sustained in human body simulated phosphate buffer saline (PBS) solution of pH 7.4 (blood pH) and pH 4.8 (intracellular lysosomal pH). This study suggests that GO could be developed as an efficient drug carrier to conjugate with PEITC for pharmaceutical applications in cancer chemotherapies. |
| Databáze: | OpenAIRE |
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