Left hemispheric deficit in the sustained neuromagnetic response to periodic click trains in children with ASD

Autor: T. M. Ovsiannikova, Olga V. Sysoeva, Tatiana A. Stroganova, Elena V. Orekhova, Andrey O. Prokofyev, Dzerasa E. Goiaeva, Tatiana S. Obukhova, K. S. Komarov
Rok vydání: 2020
Předmět:
Male
genetic structures
Sustained field (SF)
Autism Spectrum Disorder
Monaural
Audiology
lcsh:RC346-429
0302 clinical medicine
Gyrus
Child
Pitch processing
Children
05 social sciences
Neuropsychology
Magnetoencephalography
Psychiatry and Mental health
medicine.anatomical_structure
Autism spectrum disorder
Auditory Perception
Psychology
Neurotypical
Adult
medicine.medical_specialty
Speech perception
Psychometrics
behavioral disciplines and activities
050105 experimental psychology
Lateralization of brain function
Statistics
Nonparametric
03 medical and health sciences
Magnetoencephalogram (MEG)
Developmental Neuroscience
mental disorders
medicine
otorhinolaryngologic diseases
Humans
0501 psychology and cognitive sciences
Molecular Biology
Cerebrum
lcsh:Neurology. Diseases of the nervous system
Auditory Cortex
Research
40 Hz clicks
medicine.disease
Autism spectrum disorders (ASD)
Auditory steady state response (ASSR)
Acoustic Stimulation
Autism
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Molecular Autism
Molecular Autism, Vol 11, Iss 1, Pp 1-22 (2020)
ISSN: 2040-2392
Popis: Background Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses—the auditory steady state response (ASSR) and the sustained field (SF). It has been shown that the SF in neurotypical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, alternations in this auditory response may reflect atypical processing of vocal pitch. The SF, however, has never been studied in people with ASD. Methods We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in boys with ASD (N = 35) and neurotypical (NT) boys (N = 35) aged 7–12-years. Results In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher in the hemisphere contralateral to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF amplitude did not significantly change between the ages of 7 and 12 years. It was moderately attenuated in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. Limitations We did not test the language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. Conclusion Children with ASD demonstrate atypical processing of spectrally complex periodic sound at the level of the core auditory cortex of the left-hemisphere. The observed neural deficit may contribute to speech perception difficulties experienced by children with ASD, including their poor perception and production of linguistic prosody.
Databáze: OpenAIRE
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