Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma
| Autor: | Yoshihiko Kitajima, S Kido, Satoru Matsuyama, Kohji Miyazaki, Atsushi Miyoshi, Tomonori Shimonishi, Kenji Kitahara |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research Poor prognosis Pathology medicine.medical_specialty Carcinoma Hepatocellular matrix metalloproteinase Snail Matrix metalloproteinase Extracellular matrix Risk Factors biology.animal Clinical Studies parasitic diseases Gene expression medicine Humans Neoplasm Invasiveness Aged Aged 80 and over Messenger RNA biology Reverse Transcriptase Polymerase Chain Reaction Liver Neoplasms Cancer hepatocellular carcinoma Middle Aged Cadherins Prognosis medicine.disease Matrix Metalloproteinases Up-Regulation DNA-Binding Proteins Oncology Hepatocellular carcinoma Female Snail Family Transcription Factors cancer invasion Transcription Factors |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6602266 |
| Popis: | We have previously demonstrated in an in vitro study that Snail increased the invasion activity of hepatoma cells by upregulating matrix metalloproteinase (MMP) gene expression. In the present study, we examined whether Snail gene expression correlates with cancer invasion and prognosis of patients with hepatocellular carcinoma (HCC). Quantitative reverse transcription–polymerase chain reaction (RT–PCR) was performed to evaluate Snail, E-cadherin, and MMP mRNA expressions in eight nodule-in-nodule tumours and 47 ordinary HCC tissues. In the nodule-in-nodule tumours, Snail expression significantly increased with tumour dedifferentiation (P=0.047). In the ordinary HCC tissues, Snail expression was significantly correlated with portal vein invasion (P=0.035) and intrahepatic metastasis (P=0.050); it also showed a significant correlation with MT1-MMP expression (r=0.572, P |
| Databáze: | OpenAIRE |
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