When injected into the fimbria-fornix/cingular bundle, not in the raphe, 5,7-dihydroxytryptamine prevents amphetamine-induced hyperlocomotion

Autor: Fabrice Bertrand, Olivia Lehmann, Hélène Jeltsch, Bruno Will, Jean-Christophe Cassel, Christine Lazarus
Přispěvatelé: Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique (CNRS), Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS), Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2000
Předmět:
Male
medicine.medical_specialty
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
Dopamine
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
5
7-Dihydroxytryptamine
Fornix
Brain
Hippocampus
Motor Activity
Serotonergic
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Serotonin Agents
0302 clinical medicine
Dorsal raphe nucleus
Internal medicine
medicine
Animals
Rats
Long-Evans
Amphetamine
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Brain Chemistry
0303 health sciences
Raphe
Anatomy
Rats
Endocrinology
chemistry
Raphe Nuclei
Central Nervous System Stimulants
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Serotonin
Raphe nuclei
030217 neurology & neurosurgery
medicine.drug
Zdroj: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2000, 114 (1-2), pp.213-217. ⟨10.1016/s0166-4328(00)00246-1⟩
Behavioural Brain Research, Elsevier, 2000, 114 (1-2), pp.213-217. ⟨10.1016/S0166-4328(00)00246-1⟩
ISSN: 0166-4328
1872-7549
DOI: 10.1016/s0166-4328(00)00246-1
Popis: International audience; The locomotor effects of acute amphetamine treatment (1 mg/kg, i.p.) were assessed in Long-Evans rats after 5,7-dihydroxytryptamine (5, 7-DHT) injections into the fimbria-fornix/cingular bundle (FiFx/CB; 4 microg/side), or the dorsal and median raphe (Raphe; 10 microg). In control rats, amphetamine induced a significant increase of home-cage activity for about 2 h. This effect was similar in Raphe rats, but was absent in FiFx/CB rats. The raphe lesions reduced serotonin concentrations by 50% in the dorsal hippocampus, 75% in the ventral hippocampus and 58% in the fronto-parietal cortex. After FiFx/CB lesions, the reduction amounted 50, 61 and only 25%, in each of these regions, respectively. In the fronto-partietal cortex, dopamine concentration was significantly decreased in Raphe (-27%) and FiFx/CB rats (-65%). The results suggest that a serotonergic denervation of the hippocampus by injections of 5,7-DHT into the FiFx/CB pathways hampers the stimulating effects of amphetamine on locomotor activity. This effect might be related to the reduced dopaminergic tone in the fronto-parietal cortex.
Databáze: OpenAIRE
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