Vascular Endothelial Growth Factor Concentration in Chronic Subdural Hematoma Fluid Is Related to Computed Tomography Appearance and Exudation Rate
| Autor: | Ralf Weigel, Axel Hohenstein, Lothar Schilling |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty VEGF receptors Enzyme-Linked Immunosorbent Assay Computed tomography chemistry.chemical_compound Hematoma Chronic subdural hematoma medicine Humans Aged biology medicine.diagnostic_test business.industry Original Articles Exudates and Transudates medicine.disease Assay technique Vascular endothelial growth factor Vascular endothelial growth factor A chemistry Hematoma Subdural Chronic Hemorrhagic episodes biology.protein Female Neurology (clinical) Tomography X-Ray Computed business |
| Zdroj: | Journal of Neurotrauma. 31:670-673 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2013.2884 |
| Popis: | Chronic subdural hematoma (CSH) is characterized by a net increase of volume over time. Major underlying mechanisms appear to be hemorrhagic episodes and a continuous exudation, which may be studied using labeled proteins to yield an exudation rate in a given patient. We tested the hypothesis that the concentration of vascular endothelial growth factor (VEGF) in hematoma fluid correlates with the rate of exudation. Concentration of VEGF was determined in 51 consecutive patients with CSH by the sandwich immune enzyme-linked immunosorbent assay technique. Mean values were correlated with exudation rates taken from the literature according to the appearance of CSH on computed tomography (CT) images. The CT appearance of each CSH was classified as hypodense, isodense, hyperdense, or mixed density. Mean VEGF concentration was highest in mixed-density hematomas (22,403±4173 pg/mL; mean±standard error of the mean; n=27), followed by isodense (9715±1287 pg/mL; n=9) and hypodense (5955±610 pg/mL; n=18) hematomas. Only 1 patient with hyperdense hematoma fulfilled the inclusion criteria, and the concentration of VEGF found in this patient was 24,200 pg/mL. There was a statistically significant correlation between VEGF concentrations and exudation rates in the four classes of CT appearance (r=0.98). The current report is the first to suggest a pathophysiological link between the VEGF concentration and the exudation rate underlying the steady increase of hematoma volume and CT appearance.With this finding, the current report adds another piece of evidence in favor of the pathophysiological role of VEGF in the development of CSH, including mechanisms contributing to hematoma growth and CT appearance. |
| Databáze: | OpenAIRE |
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