Duration of Thyroid Dysfunction Correlates with All-Cause Mortality:The OPENTHYRO Register Cohort
| Autor: | Bo Abrahamsen, Laszlo Hegedüs, Mads Nybo, Thomas Heiberg Brix, Anne S. Laulund, Henrik L. Jørgensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors endocrine system diseases Epidemiology Denmark Science Graves' disease Thyroid Gland Thyrotropin Hyperthyroidism Cohort Studies Endocrinology Hypothyroidism Thyroid-stimulating hormone Diagnostic Medicine Internal medicine Medicine and Health Sciences medicine Humans Registries Proportional Hazards Models Multidisciplinary Proportional hazards model business.industry Mortality rate Thyroid Middle Aged medicine.disease Thyroid Diseases medicine.anatomical_structure Metabolic Disorders Cohort Medicine Female Clinical Medicine Thyroid function business Research Article Cohort study |
| Zdroj: | Laulund, A S, Nybo, M, Brix, T H, Abrahamsen, B, Jørgensen, H L & Hegedüs, L 2014, ' Duration of Thyroid Dysfunction Correlates with All-Cause Mortality : The OPENTHYRO Register Cohort ', PLOS ONE, vol. 9, no. 10, e110437 . https://doi.org/10.1371/journal.pone.0110437 PLoS ONE, Vol 9, Iss 10, p e110437 (2014) PLoS ONE |
| DOI: | 10.1371/journal.pone.0110437 |
| Popis: | INTRODUCTION AND AIM: The association between thyroid dysfunction and mortality is controversial. Moreover, the impact of duration of thyroid dysfunction is unclarified. Our aim was to investigate the correlation between biochemically assessed thyroid function as well as dysfunction duration and mortality.METHODS: Register-based follow-up study of 239,768 individuals with a serum TSH measurement from hospitals and/or general practice in Funen, Denmark. Measurements were performed at a single laboratory from January 1st 1995 to January 1st 2011. Cox regression was used for mortality analyses and Charlson Comorbidity Index (CCI) was used as comorbidity score.RESULTS: Hazard ratios (HR) with 95% confidence intervals (CI) for mortality with decreased (4.0 mIU/L) levels of TSH were 2.22; 2.14-2.30; PCONCLUSIONS AND RELEVANCE: In a large-scale, population-based cohort with long-term follow-up (median 7.4 years), overt and subclinical hyperthyroidism and overt but not subclinical hypothyroidism were associated with increased mortality. Excess mortality with increasing duration of decreased or elevated serum TSH suggests the importance of timely intervention in individuals with thyroid dysfunction. |
| Databáze: | OpenAIRE |
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