A novel chromosomal abnormality t (9;14)(p24;q13) in B-acute lymphoblastic leukemia
| Autor: | Sureshkumar Raveendran, Geetha Narayanan, Santhi Sarojam, Hariharan Sreedharan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
CD20
Janus kinase 2 CD117 CD33 CD34 Chromosomal translocation hemic and immune systems Case Report conventional cytogenetics Biology medicine.disease Leukemia medicine.anatomical_structure B-acute lymphoblastic leukemia hemic and lymphatic diseases Immunology Genetics biology.protein Cancer research medicine spectral karyotyping B Acute Lymphoblastic Leukemia Bone marrow Genetics (clinical) |
| Zdroj: | Indian Journal of Human Genetics |
| ISSN: | 1998-362X 0971-6866 |
| Popis: | Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. We describe the clinical, morphologic, immunophenotypic and cytogenetic findings in the case of a 26-year-old man with B-lymphoblastic leukemia. Surface marker analysis revealed that they are positive for CD markers CD10, CD19, CD13, CD34, CD45 and HLA-DR, but negative for CD20, CD33, CD117 and CD11C markers. Cytogenetic analysis established a novel translocation, t (9;14)(p24;q13). Apart from this, spectral karyotyping revealed an additional translocation, t (6p; 14q). This is the first documented case of B-lymphoblastic leukemia with concurrent occurrence of both abnormalities. Further studies are needed to understand the role of this abnormality in carcinogenesis. |
| Databáze: | OpenAIRE |
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