Histosurgical mapping of endoscopic endonasal surgery of sinonasal tumours to improve radiotherapy guidance

Autor: Jean-Christophe Faivre, Pierre Graff, I. Troussier, S. Servagi-Vernat, J. Villa, Vianney Bastit, Alexandre Coutte, S. Wong, C. Dupin, Yoann Pointreau, Sébastien Thureau, X. Sun, P. Giraud, Julian Biau, M. Doré, Florence Huguet, N. Vulquin, M. Alfonsi, René-Jean Bensadoun, G. Janoray, Ulrike Schick, M. Deberne, N. Wiazzane, Juliette Thariat, E. Blais, Sébastien Guihard, C. Florescu, X. Liem, S. Racadot, Emmanuel Kammerer, V. Patron, T. Leleu
Přispěvatelé: Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), CHU Amiens-Picardie
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Endoscopic endonasal surgery
Marge chirurgicale
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Postoperative radiotherapy
Chirurgie endonasale endoscopique
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Endoscopy
Resection
03 medical and health sciences
0302 clinical medicine
Margin (machine learning)
Surveys and Questionnaires
Dose painting
medicine
Radiotherapy dose
Humans
Sinonasal
Radiology
Nuclear Medicine and imaging
MESH: Surveys and Questionnaires
Chirurgie
ComputingMilieux_MISCELLANEOUS
Cancer
Radiothérapie
MESH: Paranasal Sinus Neoplasms
MESH: Humans
Radiotherapy
business.industry
Endoscopy
3. Good health
MESH: France
Radiation therapy
Margins
Oncology
Nasosinusienne
030220 oncology & carcinogenesis
Radiology
France
business
Paranasal Sinus Neoplasms
Zdroj: Cancer/Radiothérapie
Cancer/Radiothérapie, 2021, ⟨10.1016/j.canrad.2021.06.014⟩
Cancer Radiothérapie
Cancer Radiothérapie, Elsevier Masson, 2021, ⟨10.1016/j.canrad.2021.06.014⟩
Cancer/Radiothérapie, 2022, 26 (3), pp.440-444. ⟨10.1016/j.canrad.2021.06.014⟩
ISSN: 1769-6658
1278-3218
DOI: 10.1016/j.canrad.2021.06.014⟩
Popis: Purpose Endoscopic endonasal surgery (EES) is becoming a standard for most malignant sinonasal tumours. Margin analysis after piecemeal resection is complex and optimally relies on accurate histosurgical mapping. Postoperative radiotherapy may be adapted based on margin assessment mapping to reduce the dose to some sinonasal subvolumes. We assessed the use of histosurgical mapping by radiation oncologists (RO). Material and methods A French practice survey was performed across 29 ENT expert RO (2 did not answer) regarding integration of information on EES, as well as quality of operative and pathology reportsto refine radiotherapy planning after EES. This was assessed through an electronic questionnaire. Results EES was ubiquitously performed in France. Operative and pathology reports yielded accurate description of EES samples according to 66.7% of interviewed RO. Accuracy of margin assessment was however insufficient according to more than 40.0% of RO. Additional margins/biopsies of the operative bed were available in 55.2% (16/29) of the centres. In the absence of additional margins, quality of resection after EES was considered as microscopically incomplete in 48.3% or dubious in 48.3% of RO. As performed, histosurgical mapping allowed radiotherapy dose and volumes adaptation according to 26.3% of RO only. Conclusions Standardized histosurgical mapping with margin and additional margin analysis could be more systematic. Advantages of accurate EES reporting could be dose painting radiotherapy to further decrease morbidity in sinonasal tumours.
Databáze: OpenAIRE
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