A comparison of the power of two tests for qualitative interactions
| Autor: | S Piantadosi, M. H. Gail |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Statistics and Probability
Epidemiology Crossover Blood Pressure Breast Neoplasms Mice Inbred Strains Power of two Mice Risk Factors Statistics Range (statistics) Animals Humans Antihypertensive Agents Mathematics Clinical Trials as Topic Control treatment Models Statistical Data interpretation Test (assessment) Tamoxifen Treatment Outcome Sample size determination Data Interpretation Statistical Likelihood-ratio test Female |
| Zdroj: | Statistics in Medicine. 12:1239-1248 |
| ISSN: | 0277-6715 |
| DOI: | 10.1002/sim.4780121305 |
| Popis: | 'Qualitative' or 'crossover' interactions arise when a new treatment, compared with a control treatment, is beneficial in some subsets of patients and harmful in other subsets. We present a new range test for crossover interactions and compare it with the likelihood ratio test developed by Gail and Simon. The range test has greater power when the new treatment is harmful in only a few subsets, whereas the likelihood ratio test has greater power when the new treatment is harmful in several subsets. We provide power tables for both tests to facilitate sample size calculations for designing experiments to detect qualitative interactions and for interpreting the results of clinical trials. |
| Databáze: | OpenAIRE |
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