Porcine circovirus type 2 induces type I interferon production via MyD88-IKKα-IRFs signaling rather than NF-κB in porcine alveolar macrophages in vitro
| Autor: | Dianning Duan, Mengmeng Chen, Shuxia Zhang, Yaqun Zhang, Junyuan Han |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Circovirus Swine animal diseases Genome Viral Biology 03 medical and health sciences Interferon Macrophages Alveolar medicine Animals Circoviridae Infections Transcription factor Swine Diseases General Veterinary NF-kappa B virus diseases Sequence Analysis DNA biology.organism_classification Type I interferon production Cell biology I-kappa B Kinase Porcine circovirus 030104 developmental biology Immunology Interferon Regulatory Factors Interferon Type I Myeloid Differentiation Factor 88 IRF7 IRF3 medicine.drug Interferon regulatory factors Signal Transduction |
| Zdroj: | Research in veterinary science. 104 |
| ISSN: | 1532-2661 |
| Popis: | Type I interferon (IFN-I) plays important roles in host antiviral responses. The interferon regulatory factor (IRF) and NF-κB transcription factors are thought to be important in the processes of viral secretion and triggering of interferon production. Recently, studies have shown that porcine circovirus type 2 (PCV2) can induce IFN-I production in vivo and in vitro, but the mechanisms underlying the production of PAMs infected with PCV2 remains unknown. Treatment of these cells with BAY11-7082, an inhibitor of NF-κB activation, allowed us to study the secretion of IFN-α and IFN-β in PAMs infected with PCV2. We found that IFN-α expression was induced following virus infection of PAMs. Notably, even after inhibitor treatment of PAMs infected with PCV2, secretion of IFN-α was significantly higher (P |
| Databáze: | OpenAIRE |
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