| Popis: |
D URING THE LAST SEVERAL YEARS AN attempt has been made in this laboratory to arrive at an explanation of the invasiveness characteristic of malignant tumors. In contrast to benign tumor cells, which remain restricted to their site of origin, malignant cells have the ability to infiltrate adjacent tissues and thus become locally disseminated. Furthermore, their capacity for invasiveness allows them to penetrate into the lumina of lymphatic and blood vessels, whereby they are transported to more distant parts. It was thought that physical and chemical differences must exist between benign and malignant neoplastic cells which permit the former to remain localized and the latter to permeate adjacent normal tissues. Under the assumption that these differences between the types of cells were ascertainable by experimental methods, a series of investigations was made.' |
