Genome characterisation of the newly discovered avian influenza A H5N7 virus subtype combination
| Autor: | Poul Henrik Jørgensen, Anders Fomsgaard, Karoline Bragstad, Kurt Handberg |
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| Rok vydání: | 2006 |
| Předmět: |
animal structures
animal diseases Orthomyxoviridae Genome Viral medicine.disease_cause Virus Avian Influenza A Virus Virology medicine Influenza A virus Animals Gene Phylogeny Genetics biology Reverse Transcriptase Polymerase Chain Reaction virus diseases General Medicine biology.organism_classification Influenza A virus subtype H5N1 Nucleoprotein Ducks Influenza in Birds biology.protein RNA Viral Neuraminidase |
| Zdroj: | Archives of Virology. 152:585-593 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s00705-006-0860-6 |
| Popis: | In Denmark, in 2003, a previously unknown subtype combination of avian influenza A virus, H5N7 (A/Mallard/Denmark/64650/03), was isolated from a flock of 12,000 mallards. The H5N7 subtype combination might be a reassortant between recent European avian influenza A H5, H7, and a third subtype, possibly an H6. The haemagglutinin and the acidic polymerase genes of the virus were closely related to a low-pathogenic Danish H5N2 virus A/Duck/Denmark/65041/04 (H5N2). The neuraminidase gene and the non-structural gene were most similar to the highly pathogenic A/Chicken/Netherlands/1/03 (H7N7) and the human-fatal A/Netherlands/219/03 (H7N7), respectively. The basic polymerase 1 and 2 genes were phylogenetically equidistant to both A/Duck/Denmark/65047/04 (H5N2) and A/Chicken/Netherlands/1/03 (H7N7). The nucleoprotein and matrix gene had highest nucleotide sequence similarity to the H6 subtypes A/Duck/Hong Kong/3096/99 (H6N2) and A/WDk/ST/1737/2000 (H6N8), respectively. All genes of the H5N7 strain were of avian origin, and no further evidence of pathogenicity to humans has been found. |
| Databáze: | OpenAIRE |
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