Gastro-intestinal blood loss with high dose tilcotil (Ro 12-0068) and aspirin: an open crossover clinical trial and pharmacokinetic assessment in normal volunteers
| Autor: | M. McEvoy, V. Wright, D. B. Galloway, M. E. Pickup, Howard A. Bird, P. Taylor, J. R. Lowe |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Thiazines Pharmacology Piroxicam Random Allocation Blood loss Pharmacokinetics Humans Medicine Volunteer Clinical Trials as Topic Aspirin Dose-Response Relationship Drug business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Middle Aged Crossover study Clinical trial Kinetics Anesthesia Female Gastrointestinal Hemorrhage business Gastro intestinal medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 8:412-416 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007998309111747 |
| Popis: | An open crossover study was carried out in 8 normal volunteer subjects to compare faecal blood loss resulting from tilcotil (Ro12-0068), a new anti-inflammatory agent, and from enteric-coated aspirin. After a 1-week run-in period, subjects were allocated at random to receive treatment for 2 weeks with either 40 mg tilcotil as a single dose per day or aspirin, 900 mg 4-times daily, reduced if necessary to a maximum tolerated dose. Subjects were then crossed over to the alternative treatment for a further 2 weeks. The results showed that tilcotil produced less blood loss, assessed by a radioactive labelling method, and was better tolerated than aspirin. Plasma concentrations of tilcotil showed that the drug's half-life was approximately 50 hours, compatible with once daily dosage, and steady state concentrations on multiple dosing were reached after 10 to 12 days. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|