Outcome of assisted reproductive technology in different subgroups of poor ovarian responders fulfilling the POSEIDON criteria
| Autor: | Elham Sadat Mirhashemi, Maryam Eftekhar, Nasim Tabibnejad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty Future studies lcsh:QH471-489 Poor responder medicine.medical_treatment Outcome (game theory) 03 medical and health sciences 0302 clinical medicine medicine lcsh:Reproduction lcsh:R5-920 030219 obstetrics & reproductive medicine In vitro fertilisation Assisted reproductive technology Obstetrics business.industry Obstetrics and Gynecology Retrospective cohort study medicine.disease 030104 developmental biology Reproductive Medicine Live birth business lcsh:Medicine (General) |
| Zdroj: | Middle East Fertility Society Journal, Vol 23, Iss 4, Pp 399-403 (2018) |
| ISSN: | 1110-5690 |
| Popis: | Purpose: Low success rates are common in women undergoing in vitro fertilization who respond poorly to ovarian hyperstimulation. Due to the heterogeneity of the populations, expressing a unique and shared definition is necessary in order to individualize infertility treatment. The main goal of this study was to evaluate the assisted reproductive technology outcome among various subgroups of poor responders defined by the POSEIDON (Patients-Oriented Strategies Encompassing IndividualizeD Oocyte Number) stratification. Methods: In this retrospective cohort study, the clinical and laboratory records of 245 poor responder women undergoing their first ovarian stimulation and fresh embryo transfer cycle were reviewed. Patients were categorized into 4 groups according to the POSEIDON classification. Results: The fertilization rate was comparable between groups (p > 0.05). Moreover, there was no difference in implantation rates between groups 1 and 2 and groups 3 and 4 (p > 0.05). In contrast, chemical and clinical pregnancy rates, as well as live birth, were significantly higher in group 1 and 2 compared to the groups 3 and 4 (p 0.05). Conclusions: Future studies should explore the most optimal treatment strategy for poor responders according to the POSEIDON stratification and suggested handling with live birth as primary end-point. Keywords: ART outcome, Poor responder, POSEIDON stratification, Individualized treatment |
| Databáze: | OpenAIRE |
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