A prospective pilot study assessing levels of preoperative physical activity and postoperative neurocognitive disorder among patients undergoing elective coronary artery bypass graft surgery

Autor: Sawal Atmosoerodjo, Anthony Absalom, Sandra Dijkstra, Rolf C.G. Gallandat Huet, Setayesh R. Tasbihgou, Iris Tigchelaar, Massimo A. Mariani
Přispěvatelé: Cardiovascular Centre (CVC)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Sarcopenia
Cardiovascular Procedures
Social Sciences
Coronary Disease
Pilot Projects
Neuropsychological Tests
030204 cardiovascular system & hematology
Biochemistry
Postoperative Complications
0302 clinical medicine
Quality of life
Risk Factors
Medicine and Health Sciences
Psychology
Public and Occupational Health
Biomechanics
Postoperative Period
Prospective Studies
Coronary Artery Bypass
Prospective cohort study
Immune Response
Coronary Artery Bypass Grafting
Multidisciplinary
Frailty
Hand Strength
Cognitive Neurology
Incidence
Middle Aged
C-Reactive Proteins
Cardiac surgery
Neurology
Elective Surgical Procedures
Preoperative Period
Medicine
Anxiety
Female
medicine.symptom
Research Article
medicine.medical_specialty
Cardiac Surgery
Cognitive Neuroscience
Science
Prehabilitation
Immunology
Neurocognitive Disorders
Surgical and Invasive Medical Procedures
03 medical and health sciences
Signs and Symptoms
Neuropsychology
Hand strength
medicine
Humans
Exercise
Aged
Neuropsychological Testing
Sedentary lifestyle
Inflammation
business.industry
Biology and Life Sciences
Proteins
Physical Activity
Surgery
Quality of Life
Feasibility Studies
Cognitive Science
Sedentary Behavior
Clinical Medicine
business
Neurocognitive
030217 neurology & neurosurgery
Follow-Up Studies
Neuroscience
Zdroj: PLoS ONE, 15(10):e0240128. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 15, Iss 10, p e0240128 (2020)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0240128
Popis: Physical inactivity and a sedentary lifestyle are associated with a chronic low-level inflammatory state which has been implicated in the pathogenesis of cardiovascular disease. There is growing interest in exercise programs as part of surgical ‘prehabilitation’. We therefore studied preoperative physical activity levels of patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery, and performed an exploratory analysis of the influence of physical activity on postoperative outcome. The Short Questionnaire to Assess Health (SQUASH) was used to assess physical activity among 100 patients, of mean (SD) age 65.4 (7.6) years. Additionally, handgrip strength was measured, and the get-up-and-go test was conducted. Anxiety, depression, and quality of life were assessed, and a computerised cognitive test battery was used to assess cognitive performance preoperatively, and three months after surgery. Preoperatively, 76% of patients met the recommended national guidelines for physical activity. The incidence of pre-existing medical conditions, and other pre-operative patient features were similar in active and inactive patients. Preoperative physical activity was significantly inversely related to the logistic EuroSCORE. The level of physical activity was also significantly inversely related with preoperative C-reactive protein (CRP) and peak postoperative CRP, but physical activity did not appear to be associated with any adverse postoperative outcomes or extended length of hospital stay. The incidence of postoperative neurocognitive disorder (PNCD) at 3 months postoperatively was 26%. Cognitive performance was not related with physical activity levels. In summary, this was the first study to assess activity levels of cardiac surgical patients with the SQUASH questionnaire. The majority of patients were physically active. Although physical activity was associated with lower levels of inflammation in this pilot study, it was not associated with an improved clinical or cognitive postoperative outcome.
Databáze: OpenAIRE
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