Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report
| Autor: | Tomáš Guman, Marek Šarišský, Petr Gál, Miroslava Kičová, Juliana Gabzdilová, Dominika Veselinyová, Maria Giertlova, Zuzana Michalová, Martina Hajikova, Kinga Dedinská, Matúš Čoma |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cytoplasm Cancer Research Galectin 3 Galectins Chronic lymphocytic leukemia Flow cytometry 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Biomarkers Tumor medicine Humans Pathological Aged Galectin Aged 80 and over medicine.diagnostic_test business.industry Cell growth Blood Proteins General Medicine Middle Aged Prognosis medicine.disease Leukemia Lymphocytic Chronic B-Cell Pathophysiology Up-Regulation Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology Galectin-3 030220 oncology & carcinogenesis Cancer research Female Bone marrow Chromosome Deletion business Chromosomes Human Pair 17 |
| Zdroj: | Anticancer Research. 39:2805-2810 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | BACKGROUND/AIM Galectins belong to the family of galactose-binding proteins known to play an important role in the processes of cell proliferation, differentiation, migration and neoplastic progression. Herein, we studied the expression of galectin-3 (Gal-3) in chronic lymphocytic leukemia (CLL). MATERIALS AND METHODS The expression of Gal-3 was analyzed by means of multiparametric flow cytometry in normal and pathological B-cells from peripheral blood and bone marrow samples of 67 patients with CLL. RESULTS Pathological B-cells expressed significantly higher levels of cytoplasmic Gal-3 than normal B-cells. Moreover, overexpression of cytoplasmic Gal-3 was observed in the prognostically poorest subgroup of CLL patients, namely those with 17p deletion. CONCLUSION Our results indicate a possible role of galectin-3 in CLL pathophysiology and its potential value as a prognostic marker and therapeutic target. |
| Databáze: | OpenAIRE |
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