Increased population spike amplitude in the dentate gyrus following systemic administration of 5-hydroxytryptophan or 8-hydroxy-2-(di-n-propylamino)tetralin
| Autor: | Kenneth G. Baimbridge, J. M. Klancnik, Anthony G. Phillips |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Tetrahydronaphthalenes Population Hippocampus Action Potentials Naphthalenes 5-Hydroxytryptophan Internal medicine medicine Animals education Molecular Biology education.field_of_study 8-Hydroxy-2-(di-n-propylamino)tetralin Perforant Pathway Chemistry musculoskeletal neural and ocular physiology General Neuroscience Dentate gyrus Population spike Rats Inbred Strains Perforant path Entorhinal cortex Rats medicine.anatomical_structure Endocrinology nervous system Neurology (clinical) Neuroscience Developmental Biology |
| Zdroj: | Brain research. 505(1) |
| ISSN: | 0006-8993 |
| Popis: | This study investigated the effects of the serotonin (5-HT)precursor 5-hydroxytryptophan (5-HTP) and the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on population responses in the dentate gyrus evoked by perforant path stimulation. Intraperitoneal injections of either compound into urethane anesthetized rats produced a substantial increase in the amplitude of the population spike, without affecting the granular layer population EPSP. These data suggest that enhanced serotonergic tone facilitates synaptic transmission between the entorhinal cortex and dentate gyrus in vivo, and that this facilitation may be mediated by a 5-HT1A receptor. |
| Databáze: | OpenAIRE |
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