Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years
| Autor: | Jussi Lampi, Sanna Toppila-Salmi, Marjo-Riitta Järvelin, Kishor Dhaygude, Juha Pekkanen, Juha Auvinen, Annika Luukkainen, Baizhuang Xu |
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| Přispěvatelé: | HUS Inflammation Center, Department of Pathology, Department of Dermatology, Allergology and Venereology, Medicum, University of Helsinki, Helsinki University Hospital Area, Department of Public Health |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male PARENTAL SMOKING Pulmonary and Respiratory Medicine medicine.medical_specialty Offspring Population IN-UTERO CHILDREN 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine ENVIRONMENTAL TOBACCO-SMOKE Pregnancy LSM PROTEINS Wheeze Humans Medicine Cumulative incidence EXPOSURE 030212 general & internal medicine Child education Finland POPULATION Asthma RISK education.field_of_study business.industry Obstetrics Smoking CHILDHOOD ASTHMA Odds ratio Middle Aged medicine.disease respiratory tract diseases 3. Good health LUNG-FUNCTION 030228 respiratory system Prenatal Exposure Delayed Effects 3121 General medicine internal medicine and other clinical medicine Female Tobacco Smoke Pollution medicine.symptom business Follow-Up Studies |
| Zdroj: | European Respiratory Journal. 55:1901857 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/13993003.01857-2019 |
| Popis: | RationaleEnvironmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma.ObjectivesTo determine the association between prenatal ETS and adult onset asthma.Measurements and main resultsThe questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last 3 months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring was studied using adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult-onset asthma among offspring (adjusted OR 1.54, 95% CI 1.04–2.29), namely among offspring who reported either past non-diagnosed asthma (OR 9.63, 95% CI 2.28–40.67) or past cough with wheeze (3.21, 95% CI 1.71–6.05). A significant association was detected between gestational smoke exposure and the offspring's forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio at 31 years of age. In offspring with the haplotype rs11702779-AA ofRUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11–14.52, adjusted p-value for interaction 0.10).ConclusionMaternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects. |
| Databáze: | OpenAIRE |
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