Endopeptidase-24.15 in rat hypothalamic/pituitary/gonadal axis
| Autor: | James L. Roberts, Abraham Lasdun, Julia M. Ayala, Christopher J. Molineaux, Adrian R. Pierotti |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Ovariectomy Molecular Sequence Data Hypothalamus Hypothalamic–pituitary–gonadal axis Dynorphin Gonadotropin-releasing hormone Biology Biochemistry Gonadotropin-Releasing Hormone Endocrinology Estrus Anterior pituitary Internal medicine Testis medicine Animals Amino Acid Sequence Molecular Biology Progesterone Estrous cycle Ovary Metalloendopeptidases Estrogens Rats Preoptic area Kinetics medicine.anatomical_structure Pituitary Gland Female Luteinizing hormone |
| Zdroj: | Molecular and Cellular Endocrinology. 76:95-103 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/0303-7207(91)90264-s |
| Popis: | Endopeptidase-24.15 (E.C. 3.4.24.15; EP-24.15) cleaves several substrates found in the hypothalamic/pituitary/gonadal axis, including gonadotropin-releasing hormone (GnRH) and the opioid peptides of the dynorphin family. We have examined the activity of EP-24.15 in these tissues as a function of maturation, of the estrous cycle, and in response to ovariectomy and estrogen replacement. A developmental regulation of EP-24.15-specific activity is apparent in anterior pituitary, in hypothalamus, and in the gonads. EP-24.15 is increased in the preoptic area and is decreased in the anterior pituitary in both male and female rats prior to puberty. The specific activity of EP-24.15 was increased following ovariectomy in the anterior pituitary and within medial and lateral preoptic nuclei. Testicular specific activity of EP-24.15 increased with age in a linear fashion, while ovarian EP-24.15 activity increased immediately prior to puberty, but returned to prepubertal levels by 65 days of age. The relevance of EP-24.15 to the metabolism of specific peptides is discussed. |
| Databáze: | OpenAIRE |
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