Controlling Cerebellar Output to Treat Refractory Epilepsy
| Autor: | Oscar H J Eelkman Rooda, Chris I. De Zeeuw, Lieke Kros, Freek E. Hoebeek |
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| Přispěvatelé: | Neurosciences, Netherlands Institute for Neuroscience (NIN) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cerebellum
Drug Resistant Epilepsy Deep brain stimulation Vagus Nerve Stimulation medicine.medical_treatment Deep Brain Stimulation Thalamus Stimulation 03 medical and health sciences 0302 clinical medicine Neural Pathways medicine Animals Humans Generalized epilepsy 030304 developmental biology 0303 health sciences business.industry General Neuroscience medicine.disease medicine.anatomical_structure nervous system Cerebral cortex Cerebellar cortex Epilepsy Generalized business Neuroscience 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Trends in Neurosciences, 38(12), 787-799. Elsevier Ltd. Trends in Neurosciences, 38(12), 787-99. Elsevier B.V. Trends in Neurosciences |
| ISSN: | 0166-2236 |
| Popis: | Generalized epilepsy is characterized by recurrent seizures caused by oscillatory neuronal firing throughout thalamocortical networks. Current therapeutic approaches often intervene at the level of the thalamus or cerebral cortex to ameliorate seizures. We review here the therapeutic potential of cerebellar stimulation. The cerebellum forms a prominent ascending input to the thalamus and, whereas stimulation of the foliated cerebellar cortex exerts inconsistent results, stimulation of the centrally located cerebellar nuclei (CN) reliably stops generalized seizures in experimental models. Stimulation of this area indicates that the period of stimulation with respect to the phase of the oscillations in thalamocortical networks can optimize its effect, opening up the possibility of developing on-demand deep brain stimulation (DBS) treatments. |
| Databáze: | OpenAIRE |
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