Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta genTURK study
| Autor: | Ceyhun Yücel, Mehdi Zoghi, Beta GenTURK Study, Yuksel Cavusoglu, Enbiya Aksakal, Mehmet Yilmaz, Serafettin Demir, Hakki Kaya, Oktay Ergene, Haşim Mutlu |
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| Přispěvatelé: | Çukurova Üniversitesi, [Zoghi, Mehdi] Ege Univ, Dept Cardiol, Fac Med, Izmir, Turkey -- [Kaya, Hakki -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Cavusoglu, Yuksel] Osmangazi Univ, Fac Med, Dept Cardiol, Eskisehir, Turkey -- [Aksakal, Enbiya] Ataturk Univ, Fac Med, Dept Cardiol, Erzurum, Turkey -- [Demir, Serafettin] Cukurova Univ, Fac Med, Dept Cardiol, Adana, Turkey -- [Yucel, Ceyhun] Cukurova Univ, Fac Med, Balcali Hosp, Dept Cardiol, Adana, Turkey -- [Mutlu, Hasim] Istanbul Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- [Yilmaz, Mehmet Birhan] Ataturk Training & Res Hosp, Dept Cardiol, Izmir, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628 |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
socioeconomic status
Male medicine.medical_specialty Turkish population CYP2D6 lcsh:Internal medicine lcsh:Diseases of the circulatory (Cardiovascular) system Turkey Adrenergic beta-Antagonists lcsh:Medicine heart failure Heart failure Gastroenterology Gene Frequency Internal medicine Genotype Functional capacity medicine Humans Prospective Studies Prospective cohort study lcsh:RC31-1245 Aged Ejection fraction Polymorphism Genetic business.industry Medical adherence lcsh:R Stroke Volume Odds ratio Middle Aged medicine.disease Tolerability Cytochrome P-450 CYP2D6 lcsh:RC666-701 Socioeconomic status Cardiology medical adherence Female Receptors Adrenergic beta-1 Cardiology and Cardiovascular Medicine business |
| Zdroj: | Türk Kardiyoloji Derneği Arşivi, Vol 44, Iss 6, Pp 457-465 (2016) |
| Popis: | WOS: 000392631500001 PubMed ID: 27665326 Objective: The present objective was to determine frequency of Arginine389Glycine (Arg389Gly) and Cytochrome p450 2D6*10 (Cyp2D6*10) polymorphism in cases of heart failure-reduced ejection fraction (HFREF), and to evaluate the influence of the polymorphisms in response to beta-blocker (BB) therapy. Methods: A total of 206 HFREF patients and 90 healthy controls were prospectively enrolled. Genotypes for Arg389Gly and Cyp2D6*10 polymorphisms of the healthy controls and 162 of the 206 heart failure (HF) patients were measured, identified by polymerase-chain-reaction-and restriction-fragment-length-polymorphism analysis. HFREF patients and healthy controls were compared regarding Arg389Gly polymorphism. The HFREF patients were separated into 2 subgroups based on achievement of maximal target dose (MTD) of BB. Results: When comparing frequency of genotype distribution for Arg389Gly polymorphism in HFREF patients to the healthy controls, a statistically significant association was observed with CC genotype and Glisin-Glisin (GG) genotype (p |
| Databáze: | OpenAIRE |
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