Quantification of the radiation dose to the pyramidal tract using tractography in treatment planning for stereotactic radiosurgery

Autor: Kyoko Aoyagi, Osamu Nagano, Takahiro Kageyama, Masanobu Matsumoto, Masayuki Kase, Kohei Kawasaki
Rok vydání: 2017
Předmět:
Adult
Male
Organs at Risk
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Pyramidal Tracts
Physical Therapy
Sports Therapy and Rehabilitation
Lesion volume
Radiosurgery
030218 nuclear medicine & medical imaging
Young Adult
03 medical and health sciences
0302 clinical medicine
Image Processing
Computer-Assisted
medicine
Humans
Radiology
Nuclear Medicine and imaging
Child
Radiation Injuries
Radiation treatment planning
Aged
Aged
80 and over
Radiation
Pyramidal tracts
medicine.diagnostic_test
Brain Neoplasms
Phantoms
Imaging
business.industry
Radiotherapy Planning
Computer-Assisted
Radiation dose
Radiotherapy Dosage
Magnetic resonance imaging
General Medicine
Middle Aged
Magnetic Resonance Imaging
Radiation therapy
medicine.anatomical_structure
Female
Radiology
business
Nuclear medicine
030217 neurology & neurosurgery
Tractography
Zdroj: Radiological Physics and Technology. 10:507-514
ISSN: 1865-0341
1865-0333
Popis: In stereotactic radiosurgery for intracranial lesions, optimization of the dose to the at-risk organs is important to avoid neurological complications. We aimed to quantify the dose to the pyramidal tract (PT) and improve treatment planning for gamma knife radiosurgery by combining tractography. Pyramidal tractography images were depicted in 23 patients with lesions adjacent to the PT and fused with stereotactic magnetic resonance images. We regarded the PT as an at-risk organ and performed dose planning. To assess the efficacy of this process, we compared clinical parameters between plans with and without tractography. In the plans with tractography, the maximum PT dose was significantly reduced, although the irradiation time was prolonged by 3.5 min. There was no significant difference in the dose covering 95% of the lesion volume (D95). This result suggests that the PT dose can be reduced while maintaining the D95 with clinically acceptable prolongation of the irradiation time.
Databáze: OpenAIRE
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