Synthesis, characterization and assessment of hydrophilic oxidized carbon nanodiscs in bio-related applications
| Autor: | Georgia Potsi, Panagiota Zygouri, Theodore Steriotis, Fotios K. Katsaros, Antonios Kouloumpis, Petra Rudolf, Michaela Patila, Georgia Charalambopoulou, Zili Sideratou, Theodoros Tsoufis, A. Sevastos, Dimitrios Gournis, Haralambos Stamatis |
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| Přispěvatelé: | Surfaces and Thin Films |
| Rok vydání: | 2018 |
| Předmět: |
DOXORUBICIN
Materials science Nanostructure General Chemical Engineering NANOTUBES chemistry.chemical_element Graphite oxide 02 engineering and technology 010402 general chemistry NANOSTRUCTURES 01 natural sciences CYTOCHROME-C law.invention chemistry.chemical_compound THIN-FILMS CHEMISTRY law Thin film NANOPARTICLE SIZE Graphene General Chemistry 021001 nanoscience & nanotechnology GRAPHITE OXIDE 0104 chemical sciences Characterization (materials science) NANOCONES chemistry Chemical engineering GRAPHENE OXIDE Nanocarriers 0210 nano-technology Carbon Derivative (chemistry) |
| Zdroj: | RSC Advances, 8(1), 122-131. ROYAL SOC CHEMISTRY |
| ISSN: | 2046-2069 |
| Popis: | Oxidation of industrially prepared carbon nanodiscs using a simple, versatile, and reproducible approach based on the Staudenmaier method yields a new hydrophilic form of nanocarbon. As a result of the strong acid treatment, which also enables the separation of carbon nanodiscs from the mixed starting material, the graphene planes detach from the discs, while the surface of the carbon nanodiscs is decorated with various oxygen-containing functional polar groups. Thus, the completely insoluble carbon nanodiscs are converted to a hydrophilic derivative dispersable in many polar solvents, including water. The new carbon structure is expected to have a wide range of applications in several fields including bioapplications. To this end, the functionalized carbon nanodiscs exhibit very low cytotoxicity, while they achieve high drug loadings, enabling their application as an effective drug nanocarrier. Furthermore, the carbon disks were evaluated as supports in nanobiocatalytic applications, increasing significantly the stability of the systems, due to carbon disks' nano-sized dimensions. |
| Databáze: | OpenAIRE |
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