Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives
| Autor: | Vincenzo De Simone, Raffaele Calabrò, Luigi Aronne, Carmine Siniscalchi, Maria Credendino, R. Mocerino, Giovanni Maria Di Marco, Francesco Natale, Paolo Calabrò, Maurizio Cotrufo, M A Tedesco |
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| Přispěvatelé: | Natale, F, Tedesco, Ma, Mocerino, R, DE SIMONE, V, DI MARCO, Gn, Aronne, L, Credendino, M, Siniscalchi, C, Calabro', Paolo, Cotrufo, M, Calabro', Raffaele |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Waist Population Blood Pressure Carotid IMT Intra-Abdominal Fat Essential hypertension Young Adult Risk Factors Internal medicine medicine.artery Humans Medicine Outpatient clinic Radiology Nuclear Medicine and imaging Obesity cardiovascular diseases Common carotid artery education Aged Aged 80 and over Echocardiography Doppler Pulsed education.field_of_study business.industry General Medicine Middle Aged medicine.disease Pulse pressure Arterial stiffne Carotid Arteries Blood pressure Adipose Tissue Echocardiography Hypertension Linear Models cardiovascular system Arterial stiffness Cardiology Female Visceral adiposity Waist Circumference Epicardial fat Cardiology and Cardiovascular Medicine business Pericardium |
| Zdroj: | European Journal of Echocardiography. 10:549-555 |
| ISSN: | 1532-2114 1525-2167 |
| DOI: | 10.1093/ejechocard/jep002 |
| Popis: | Aims Relationship between obesity and cardiovascular (CV) disease depends not only on the amount of body fat, but also on its distribution. For example, individuals with increased fat accumulation in the abdominal region have atherogenic lipid profiles and are at increased CV risk. The loss of elasticity in medium and large arteries is an early manifestation of atherosclerosis. The aim of this study was to evaluate whether echocardiographic epicardial adipose tissue, an index of cardiac adiposity, is related to carotid stiffness and carotid intima-media thickness (IMT), indexes of subclinical atherosclerosis, better than waist circumference in hypertensive patients.Methods and results We studied 459 patients with Grade I and II essential hypertension who were referred to our outpatient clinic over a period from May 2007 to March 2008. The population was first sorted by waist circumference and then by epicardial fat ≤7 or >7 mm. We measured epicardial fat thickness, waist circumference, carotid artery stiffness, and carotid IMT in all patients. Patients divided according to waist circumference showed no statistical differences in carotid artery stiffness between the two groups. Subjects with epicardial fat >7 mm were older, had higher systolic, diastolic, and pulse pressure, increased left ventricular mass index, carotid IMT, diastolic parameters, and stiffness parameters compared with those with epicardial fat ≤7 mm (P < 0.001). A positive correlation was found between epicardial fat and age, pulse pressure, stiffness parameters, carotid IMT, systolic blood pressure, and duration of hypertension, and a negative correlation was found with diastolic parameters. Age, carotid IMT, and stiffness parameters were independently related to epicardial fat.Conclusion Our findings indicate that epicardial fat reflects carotid artery stiffness in hypertension-induced organ damage. © The Author 2009. |
| Databáze: | OpenAIRE |
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